Causes of Fulminant Hepatic Failure in Children	
		
Etiology	Age prevalence	
Infectious		
Hepatitis A virus
Hepatitis B virus
Hepatitis C virus
Hepatitis D virus
Herpes simplex virus type I and II
Herpes zooster virus
Citomegalovirus
Epstein Barr virus	Infants
Neonates, infants
Infants; 2-10 years
Rare
Rare, in neonates or immunocompromized
Rare, in neonates or immunocompromized
Rare, in neonates or immunocompromized
Rare, in neonates or immunocompromized	
Hepatotoxic agents		
Acetaminophen (overdose)
Amanita
Salycilate (overdose)	Infants; 2-10 years	
Drugs plus idiosyncratic reactions		
Isoniazid
Propyltiouracil	Rare in children	
Metabolic		
Hereditary fructose intolerance 
Galactosemia 
Tyrosinemia 
Neonatal hemochromatosis 
Wilson’s disease 
Fatty liver of pregnancy	Neonates; infants
Neonates
Neonates
Neonates
10-18 years
10-18 years	
Autoimmune hepatitis 	All	
Ischemia and abnormal perfusion		
Congenital heart disease
Cardiac surgery
Myocarditis
Severe asphyxia
Budd-Chiari syndrome 	Neonates; infants
Neonates; infants; 2-18 years
Neonates; infants; 2-18 years
Neonates; infants; 2-18 years
2-18 years	
Malignancy		
Hepatoblastoma 
Metastatic malignancy	Rare, in 2-10 years old